Hiring: Staff/ Senior/ Principal Systems Engineer - R&D Company: Culture Biosciences Location: South San Francisco, CA Job Posted Time: 2026-09-13 10:33:20 Employment Type: Full-time Target Skills & Keywords : CAD, Embedded Systems, Firmware, Python, R, Systems Design About the job Experience: •15+ years of Industry experience with 10+ years in the biopharma, biotech, or life science field. •Significant experience architecting and integrating complex R&D systems (multi-disciplinary: hardware + software/controls + test). •Strong track record of leading cross-functional technical decisions and delivering integrated prototypes that meet defined acceptance criteria. •Expert ability to write concise system requirements and define interfaces that reduce integration churn. •Deep hands-on troubleshooting capability in lab environments with instrumentation, data-driven debugging, and structured RCA. Required Skills: •System architecture ownership: Define the end-to-end architecture, subsystem boundaries, and interfaces across mechanical, electrical, firmware/software, controls, and test. •Integration strategy: Build the integration plan (bring-up sequencing, dependency mapping, integration test strategy) and lead cross-functional execution through integration milestones. •Technical tradeoff studies: Lead tradeoffs of performance, reliability, safety, cost, manufacturability, and document decisions, assumptions, and risks. •Verification strategy in R&D: Define verification intent early (what “works” means), build coverage plans, and ensure prototypes generate evidence—not just demos. •Validation strategy for end use: Assist with Validation development and help establish plans that relate to User Needs. Interface with Application teams and Early Adopters in validating their workflows. •Complex debugging & Root Cause Analysis: Drive root-cause across subsystems; implement corrective actions and regression prevention (design changes, test additions, process updates). •Design review leadership: Lead system-level design reviews and readiness gates around architecture, integration readiness and verification readiness. •Standards & mentorship: Create templates/best practices and mentor other systems engineers and tech leads. Qualifications: •Advanced degree (Masters or PhD preferred) in Bioengineering, Chemistry, Biology, or a related field. Compensation: •$165,000 - $260,000 / year •Competitive benefits and rewards package •Culture Biosciences's compensation package includes market competitive salary, equity for all full time roles, and great benefits Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!