Hiring: Senior Scientist, Protein Engineering Company: Flagship Pioneering Location: Cambridge, MA Job Posted Time: 2026-09-09 17:58:09 Employment Type: Full-time Target Skills & Keywords: Protein Engineering, Membrane Protein Engineering, Molecular Biology, Surface Display Technology, Construct Design, Plasmid Engineering, DNA Libraries, Oligo Libraries, High-Throughput Pooled Screens, Mammalian Cell Expression, Assay Development, Design-Build-Test Cycles, Biochemistry, Bioengineering Experience: - PhD in molecular biology, protein engineering, biochemistry, bioengineering, or a similar field - 5+ years of industry or postdoctoral experience - Demonstrated expertise in membrane protein construct design and engineering - Deep hands-on molecular biology expertise, including construct design and practical experience ordering, building, and troubleshooting many constructs in parallel Required Skills: - Design, engineer, and iteratively optimize novel membrane protein constructs across a range of architectures and topologies - Troubleshoot construct design, expression, and folding for challenging membrane proteins - Perform molecular biology and plasmid engineering at scale, including construct design, ordering, QC, and sequence verification - Design and run assays to characterize construct expression and performance - Drive design-build-test cycles - Optimize workflows and establish best experimental and documentation practices - Collaborate with screening and translational colleagues to ensure constructs are fit for downstream pooled selection and functional readouts - Translate experimental data into meaningful insights and present results at team meetings Qualifications: - Highly innovative scientist with deep molecular biology expertise - Strong track record in membrane protein engineering and surface display technology - Rigorous, proactive, and energized by shaping scientific direction and team culture - Experience designing and building DNA and oligo libraries for high-throughput pooled screens - Experience validating construct expression in mammalian cells - Ability to leverage established scaffolds, structures, and published methods while also creating novel designs Compensation: Not specified Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don’t miss this opportunity to join a forward-thinking team!