Hiring: Senior Scientist II (Pharmacology) Company: Exelixis Location: Alameda, CA Job Posted Time: 2026-09-10 11:46:32 Target Skills & Keywords : Microsoft Office, tox About the job Experience: •Comprehensive expertise in in vivo Pharmacology (PK, PD, and efficacy) concepts for the oncology drug discovery. •Extensive experience using in vivo tumor models for drug discovery with a proven track record in establishing, validating, and implementing animal models for testing cancer therapies, including xenograft, syngeneic, genetically engineered mouse, orthotopic, PDX, and humanized models to study biologic mechanisms. •Demonstrated success in writing regulatory and IND filing documents in the pre-clinical Pharmacology section. •Demonstrated success in good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale. •Expertise in cell culture with aseptic technique and basic vivo techniques is a must. Required Skills: •Lead, design, execute, and interpret in vivo pharmacology (PK/PD/Efficacy) experiments to test the selected compounds in rodent tumor models. •Establish PK/PD/Efficacy relationship and be able to characterize the Tox profile by using the preclinical animal models for the therapeutic candidates. •Represent the Pharmacology function or act as Project Team Co-Lead (PTL) on Discovery project teams. •Provide scientific support for the project teams and Discovery/ Pharmacology staff. •Utilize literature and internal data sets to design and test hypotheses for drug targets. •Prepare Pharmacology study reports for research findings and support IND filings. •Partner cross-functionally with the IACUC committee to ensure compliance with internal policies and animal welfare regulations. •May manage a team in the Pharmacology group Qualifications: •PhD in Pharmacology, Cancer Biology, Molecular Cellular Biology, or a closely related field with a minimum of 2 years of industrial experience after post-doctoral training; or Equivalent combination of education and experience •In vivo skills include, but are not limited to, animal handling, dosing with different routes, blood collection, tissue collection/ perfusion, necropsy, tumor measurement, clinical observation, and rodent survival surgeries. •Understanding the regulations and guidelines of IACUC and AAALAC is a must. •Has flexibility to adapt to a fast-paced work environment and deadlines. •Demonstrated capacity to work in a team-based environment and coach junior scientists. •Excellent oral and written communication and presentation skills. •Detail-oriented and able to solve problems and offer potential solutions. •Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively either in a team environment or independently. •Advanced knowledge of MS Office, PDF, GraphPad, ELN notebook, and Studylog is required. •Work on problems of diverse scopes where analysis of data requires evaluation of identifiable factors. Compensation: •$132,500 - $188,000 / year •Flexible work environment (work from home / hybrid options) Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!