Hiring: Senior Scientist, Cardiac Modeling Company: insitro Location: South San Francisco, CA Job Posted Time: 2026-09-12 10:27:05 Employment Type: Hybrid About the job Experience: •3 years of industry experience iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms •At least 3 years of industry experience iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms Required Skills: •IPSC-CM Platform & Model Development •Differentiation & QC: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline •2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality •Genetic Disease Models: Build and apply isogenic iPSC-CM disease models — including CRISPR-edited lines carrying disease-associated variants — to study cardiovascular pathophysiology •Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease —contractility, electrophysiology, calcium handling, stress responses — in formats compatible with high-throughput data acquisition •Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform •Experiment Design for ML: Partner with ML and computational biology teams to design experiments that generate high-quality training data and to interpret model outputs in biological context •Target Identification: Contribute to target identification and validation efforts by connecting cellular phenotypes to human genetic evidence Qualifications: •Advanced Degree: Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms •Genetic Disease Modeling: Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs — to study cardiovascular mechanisms •Cardiovascular Biology: Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease •High-Content Imaging: Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines •Human Genetics: Familiarity with GWAS and human genetic evidence, and experience using these data to prioritize disease mechanisms or therapeutic targets •Scientific Communication: Track record of executing rigorous experiments and communicating findings clearly in publications, presentations, or internal reports •ML Curiosity: You're enthusiastic about working alongside ML scientists and understand how experimental design shapes what a model can learn •Builder Mentality: You thrive building systems from the ground up and bring the same rigor to a new workflow as to a published experiment •Cross-functional Collaborator: You work fluidly across biology, computation, and chemistry, and communicate clearly across disciplines •Independent & Adaptive: You drive projects forward independently in a fast-paced environment while staying aligned with team priorities Compensation: •$156,000 - $166,000 / year Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!