Hiring: Senior Scientist, Biology Company: Flagship Pioneering Location: Cambridge, MA Job Posted Time: 2026-09-16 15:58:09 Employment Type: Full-time Target Skills & Keywords : Cell Isolation, Cell Sorting, FACS, MACS, Flow Cytometry, FlowJo, siRNA, Gene Silencing, In Vivo Mouse Studies, In Vitro Studies, Advanced Microscopy, Confocal Imaging, Live-Cell Imaging, High-Content Imaging, Target Validation, Mechanism of Action, Biomarker Discovery, Translational Research, Preclinical Research, Molecular Biology, Cell Biology, Immunology, Pharmacology, CRO Collaboration, Mentorship Experience: - Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a related field with 6+ years of relevant experience for Senior Scientist roles - 8+ years of industry experience and demonstrated scientific leadership for Principal Scientist roles - Alternatively, an M.S. degree with substantial relevant industry experience - Hands-on experience with cell isolation techniques, including tissue dissociation and magnetic bead-based separation - Extensive experience with mouse models and in vitro experimental techniques Required Skills: - Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis using FlowJo or equivalent software - Deep expertise in cell isolation and sorting - In vivo and in vitro mouse studies - Gene-silencing technologies (siRNA) - Advanced microscopy techniques - Design, execute, and analyze complex in vitro and ex vivo experiments - Multi-parameter flow cytometry assays, including panel design, optimization, troubleshooting, and data interpretation - Cell isolation and cell sorting (e.g., FACS, MACS) from various tissues and biological samples - In vivo mouse studies, including disease model development, dosing, tissue collection, and phenotypic characterization - siRNA-based approaches for target validation, pathway interrogation, and mechanistic studies - Microscopy-based experiments, including fluorescence, confocal, live-cell, and high-content imaging, and analysis of imaging datasets - Complementary molecular and cellular biology techniques for target validation and mechanism-of-action studies - Cell profiling experiments using flow cytometry, imaging, and molecular approaches - Biomarker discovery, translational research, and preclinical candidate characterization - Analyze, interpret, and present experimental findings to cross-functional teams and senior leadership - Generate technical reports, presentations, study summaries, and scientific documentation - Collaborate with internal teams, CROs, academic collaborators, and external partners - Mentor junior scientists - Maintain accurate experimental records and ensure compliance with institutional, ethical, and regulatory guidelines Qualifications: - Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a related field - 6+ years of relevant experience for Senior Scientist roles - 8+ years of industry experience and demonstrated scientific leadership for Principal Scientist roles - Alternatively, an M.S. degree with substantial relevant industry experience - Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis using FlowJo or equivalent software - Hands-on experience with cell isolation techniques, including tissue dissociation and magnetic bead-based separation - Extensive experience with mouse models and in vitro experimental techniques - Demonstrated expertise in gene-silencing technologies (siRNA) and advanced microscopy techniques - Ability to lead research initiatives, mentor team members, manage external collaborations, and contribute to scientific and program strategy - Highly motivated and experienced scientist with strong leadership capabilities Compensation: Not specified Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don’t miss this opportunity to join a forward-thinking team!