Hiring: Senior Director, Oncology Pharmacology Company: Jazz Pharmaceuticals Location: Philadelphia, PA Job Posted Time: 2026-09-14 14:05:04 Target Skills & Keywords : HTML, Project Management About the job Required Skills: •This individual will be responsible for leading scientific team members assigned to oncology assets ranging from discovery through regulatory approval. •This individual will both manage the oncology pharmacology team and serve a lead on one or more programs themselves. •The oncology pharmacology team cross-functional, including participation in matrix teams assigned to specific products that include but are not limited to Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers Regulatory Affairs, and Project Management. •Partner cross-functionally with and represent ORP on internal teams—to design, develop, implement, and oversee execution of strategies and experiments supporting nonclinical studies in hematologic malignancies and solid tumors. •Design and execute experiments to elucidate efficacy, tolerability, mechanism of action, and biomarkers associated with complex combinations of multiple therapeutic modalities (small molecules, biologics, ADCs, bi-specifics, cell therapies, and other emerging platforms). •Critically evaluate biochemical and cellular assays. •Communicate effectively across JAZZ functional teams, highly matrixed, cross functional environments. •Demonstrate strong interpersonal, negotiation, and influence skills. Qualifications: •Industry experience evaluating therapeutic potential of drug candidates from hit to lead optimization through IND enabling studies, with deep expertise in oncology drug development. •Broad background in preclinical oncology with strong familiarity with emerging therapeutic modalities, competitive landscapes, and strategic assessment of diverse drug mechanisms. •Extensive experience in Immuno Oncology (I/O), including I/O relevant in vivo and in vitro models, immune cell biology, and integration of immunological endpoints into pharmacology programs. •Demonstrated experience working across multiple drug modalities, including small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell and gene therapies, and RNA based therapeutics. •Strong foundational understanding of the interdependencies between Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology, including how these functions integrate to enable successful dose selection, therapeutic index characterization, risk assessment, and translational strategy. •Comprehensive expertise in cancer signaling pathways and their therapeutic exploitation. •Proven experience leading multiple complex pharmacology programs at diverse CROs, including GLP and non-GLP environments. •Expertise designing and executing studies evaluating efficacy, tolerability, mechanism of action, and biomarker strategies for small molecule and biologic agents. •Demonstrated capacity to integrate preclinical and clinical datasets, innovate, and apply novel methodologies to advance therapeutic programs. •Proficiency with analytical tools (e.g., GraphPad Prism) and biomarker data analysis. Compensation: •$232,000 - $348,000 / year •Internal equity considerations will also influence individual base pay decisions Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!