Hiring: (Scientist) Sr. Scientist, Cardiovascular and Metabolic Disease Company: Flagship Pioneering Location: Cambridge, MA Job Posted Time: 2026-09-02 17:58:09 Employment Type: Full-time Target Skills & Keywords: Cardiovascular & Metabolic Disease, Target Validation, Drug Discovery, Translational Biology, In Vitro & In Vivo Models, Proteomics, CRISPR, ELISA, qPCR, Western Blotting, RNAseq, Assay Development, Multi-omics Data Integration Experience: - 2+ years (Scientist) or 5+ years (Senior Scientist) of relevant postdoctoral or industry experience - Postdoctoral training or industry experience strongly preferred - Experience working in biotech or pharma - Hands-on expertise in cellular/molecular biology techniques and assay development Required Skills: - Design, execute, and interpret mechanistic studies using state-of-the-art models and technologies - Lead target validation efforts informed by proteomic and computational insights - Collaborate with computational biology and proteomics teams to interpret large-scale datasets (proteomic, transcriptomic, genetic) - Design and oversee in vitro and in vivo models of disease for target biology, candidate selection, biomarker development, and proof-of-concept studies - Cellular assays and in vitro pharmacology assays - Cellular/molecular biology techniques (e.g., CRISPR, ELISA, qPCR, Western blotting, RNAseq) - Strong track record of scientific contributions (publications, patents, presentations) - Excellent communication, collaboration, and organizational skills Qualifications: - Ph.D. in physiology, pharmacology, cell biology, or a related field - Deep understanding of disease mechanisms and translational models in one or more areas: obesity, type 2 diabetes, atherosclerosis, heart failure, MASH, lipid metabolism, or vascular disease (preferred) - Ability to integrate multi-omic or genetic data into experimental design (preferred) - Familiarity with target identification and validation processes (preferred) Compensation: Not specified Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don’t miss this opportunity to join a forward-thinking team!