Hiring: Scientist Company: BioSpace Location: Philadelphia, PA Job Posted Time: 2026-09-11 11:44:25 Employment Type: Full-time Target Skills & Keywords : R About the job Experience: •2 years of experience in the field of cell and gene therapy, in vivo CAR-T experience preferred. Required Skills: •Design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T. •Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems. •Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models. •Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays. •Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis. •Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN. •Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums. •Maintain compliance with GLP and EHS protocols. Qualifications: •PhD in Immunology or related discipline. •Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays. •Track record of productivity is evidenced by publications or patents. •Be able to work independently to plan and timely execute research projects •Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred •Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies •Strong experience with lentivirus production, tittering and transduction. •Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors •Strong multitasking, problem-solving and collaborative skills Excellent verbal and written communication skills •The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Compensation: •$96,267 - $126,351 / year Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!