Hiring: Scientist III, Process Chemistry (Antibody-siRNA Conjugates) Company: Arrowhead Pharmaceuticals Location: Madison, WI Job Posted Time: 2026-09-03 14:41:45 About the job Experience: •10+ years of relevant experience. Required Skills: •Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up. •Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment. •Work hands-on in the laboratory to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies. •Oversee and direct CROs/CDMOs executing process development and manufacturing activities, including setting technical direction, reviewing data, and ensuring timelines and quality standards are met. •Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using relevant analytical methods (e.g., HIC, SEC, IEX, LC-MS, AEX). •Lead technology transfer to internal and external manufacturing partners, authoring process descriptions, batch records, and development reports. •Troubleshoot process and analytical challenges; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation. •Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams Qualifications: •PhD. in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or a related field with some relevant industry experience; or a Master's degree in a related field with 10+ years of relevant experience. •Demonstrated hands-on experience in siRNA conjugation development is required. •Solid functional working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods. •Operational familiarity with purification and analytical characterization of conjugates. •Strong problem-solving, documentation, and communication skills. •Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry). •Wisconsin pay range {{:}} $110,000 USD - $125,000 USD •Arrowhead provides competitive salaries and an excellent benefit package. •Candidates must have current, valid authorization to work in the country where this role is located. Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!