Hiring: Scientific Director, Process Chemistry - Oligonucleotides Company: Eli Lilly and Company Location: Indianapolis, IN Job Posted Time: 2026-09-14 14:41:45 Employment Type: Contract Target Skills & Keywords : Foundry, Project Management About the job Experience: •5+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC); or MS in a relevant scientific discipline with 8+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC). Required Skills: •Bring extensive oligonucleotide CMC expertise to SMDD and grow internal capability through coaching, mentorship, and technical leadership across a diverse portfolio — complex single strands, siRNA, and oligonucleotide conjugates (AOC and PRC). •Develop and apply impurity control strategies aligned with the current global regulatory climate; address CMC regulatory questions enabling clinical studies and marketing authorization applications. Prior experience in validation activities preferred. •Provide technical leadership across route design, process development, equipment selection, and scale-up — from laboratory plans through demonstration on development- and commercial-scale equipment, partnering with internal manufacturing (Lilly Medicine Foundry) and external CMOs to deliver robust processes for clinical and commercial supply. •Demonstrate strong skills with automated reactor platforms and purification technologies and apply them across the oligonucleotide portfolio. •Collaborate across internal CMC networks (Drug Product Delivery, Project Management, Quality, Manufacturing, and Regulatory) to deliver materials and documentation for clinical trials and regulatory submissions. •Identify and integrate external chemistry innovations to complement internal capabilities; represent Lilly externally through presentations at symposia and consortia and publications in peer-reviewed journals. •Contribute novel chemical design and mechanism-based problem solving (e.g., total synthesis, methodology development, oligonucleotide synthesis), reflected in a strong peer-reviewed publication record. •Lead through ambiguity and change; encourage initiative, accountability, and diverse perspectives across the team. Qualifications: •PhD in a relevant scientific discipline with 5+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC); or MS in a relevant scientific discipline with 8+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC). •Strong interpersonal skills and a collaborative working style. •Demonstrated initiative and appropriate risk-taking. •Demonstrated technical proficiency and ability to create ideas for future work plans. •Strong technical skills that deliver business value. •Knowledge and experience with management of a technical project. •Demonstrated leadership capabilities, especially in a team environment. •Demonstrated capacity to prioritize multiple activities and manage ambiguity. •Demonstrated capacity to influence others to promote a positive work environment. •Demonstrated success in persuasion, influence, and negotiation. Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!