Hiring: Director, Quantitative Systems Pharmacology Company: Eisai US Location: Nutley, NJ Job Posted Time: 2026-09-12 11:48:13 Target Skills & Keywords : R About the job Required Skills: •Use and improve existing Neurology QSP Platforms to gain insights into the causal relationships between biological and drug-level responses, enhancing the understanding of drug-target interactions and disease mechanisms. Develop new QSP models and platforms as they are needed. •Lead DHBL preclinical and early clinical QSP development strategy to support optimal dose selection with simulations based on mechanistic understanding to assess efficacy and safety. •Advocate for model-informed drug discovery and development (MIDD) approaches. Provide scientific leadership, present research at scientific conferences, and integrate MIDD strategies into Eisai’s R&D programs to improve efficiency and decision-making. •Foster collaboration across functional groups and promote the development of new modeling tools and methods. Advance the adoption of QSP capabilities to improve the predictive power of these tools to support the design and optimization of drug combinations. •Manage the expectations/timelines of assigned M&S work for the relevant project teams. •Use mathematical, computational, and statistical tools to analyze and interpret large, complex data sets to gain insights into the causal relationships between drug-target interactions and disease mechanisms. •Provide scientific/strategic expertise across multiple therapeutic areas to support decision-making in the conversion of discovery to clinical through the design, development, and execution of quantitative mechanistic models to support the translational process. Qualifications: •PhD, MD-PhD and/or PharmD in Bioengineering, Systems Biology, Applied Mathematics, Computational Biology, Pharmacometrics, Chemical Engineering, Pharmaceutical Sciences, or a related quantitative discipline. •Deep knowledge of the principles and theoretical aspects of applied mathematical modeling, including numerical methods, ordinary differential equations (ODEs), partial differential equations (PDEs), parameter estimation/optimization, and how these tools can be applied in the development of complex biochemical models. •Deep expertise in quantitative systems pharmacology (QSP), mechanistic modeling, systems biology, and translational science. •Demonstrated experience applying QSP approaches to support drug discovery and/or clinical development programs with measurable program impact. •In-depth knowledge of pharmacology, physiology, immunology, molecular biology, and disease mechanisms. •Demonstrated capacity to learn quickly in new areas of biology and to use a solid foundation of quantitative skills to apply newly acquired knowledge to build mechanistically sound QSP models. •The annual base salary range for the Director, Quantitative Systems Pharmacology is from :$208,200-$273,200 •Under current guidelines, this position is eligible to participate in : Eisai Inc. Annual Incentive Plan & Eisai Inc. Long Term Incentive Plan. •Final pay determinations will depend on various factors including but not limited to experience level, education, knowledge, and skills. •Employees are eligible to participate in Company employee benefit programs. For additional information on Company employee benefits programs, visit https://careers.eisai.com/us/en/compensation-and-benefits. Compensation: •$208,200 - $273,200 / year Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!