Hiring: Associate Scientist III, Cardiac Modeling Company: insitro Location: South San Francisco, CA Job Posted Time: 2026-09-16 10:27:05 Employment Type: Hybrid About the job Experience: •2 years of relevant experience in the biotech/biopharma industry •At least 2 years of relevant experience in the biotech/biopharma industry Required Skills: •Based in South San Francisco, this position reports directly to Senior Scientist, Cardiometabolic Disease - Translational Genetics and requires you to be onsite at our South San Francisco office •IPSC-CM Platform & Model Development •Differentiation & QC: Support the generation and maintenance of iPSC lines and their differentiation into cardiomyocytes in 2D format (monolayers), implementing rigorous quality control points at each stage of the pipeline and with emphasis on production scalability •Genetic Disease Models: Assist in building isogenic iPSC-CM disease models — including patient and CRISPR-edited lines carrying disease-associated variants — and characterizing the cellular model to study cardiovascular pathophysiology •Functional Readouts: Support the development and optimization of functional assays relevant to cardiovascular disease —contractility, electrophysiology, calcium handling, stress responses, high-content imaging — in formats compatible with high-throughput data acquisition •Rigor & Reproducibility: Documentation including writing/reviewing technical procedures and SOPs, presentation of results in team meetings and maintaining laboratory notebook with scientific rigor •Target Identification: Contribute to target identification and validation efforts by connecting cellular phenotypes to human genetic evidence, aligning around the team and company goals to advance drug discovery Qualifications: •Cell culture and iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation and iPSC-CM model characterization in 2D (monolayer) format. Prior experience in 3D/engineered heart tissue platforms or organoids is a plus •Genetic Disease Modeling: Previous experience developing genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs — to study cardiovascular mechanisms •Cardiovascular Biology: Background in cardiomyocyte biology and/or cardiovascular disease is preferred •Functional Assays: Experience with functional assays relevant to cardiomyocyte biology (contractility, calcium, electrophysiology, imaging, stress responses). Prior exposure and experience working with high-throughput platforms and/or automated systems is a plus •Molecular Assays: Hands-on expertise in molecular assays, such as PCR, RT-qPCR, Western Blot and immunofluorescence •Scientific Communication: Track record of executing rigorous experiments and communicating findings clearly in publications, presentations or internal reports •Cross-functional and Curious Collaborator: You are comfortable managing multiple tasks efficiently, communicating clearly and effectively, building open and collaborative relationships and are curious about implementing novel ML models into functional biology •Independent & Adaptive: You thrive in a fast-paced environment working both independently and as part of a small, dedicated team while staying aligned with the team objectives •Scientific Rigor and Attention to Detail: You excel at designing and executing experiments with the utmost scientific rigor, strong attention to detail and a positive and go-getter attitude towards unexpected results and challenges •Our target starting salary for successful US-based applicants for this role is $107,000 - $114,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. Compensation: •$107,000 - $114,000 / year Interested candidates, please apply directly through the job posting on company's career page or try via AI auto apply on this platform. Don't miss this opportunity to join a forward-thinking team!